Thu, 24 Jul 2008 19:52:30 BST CiteULike: lechristophe Garcia http://www.citeulike.org/user/lechristophe/author/Garcia CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/lechristophe/article/2712150 <i>Cellular and molecular life sciences : CMLS (14 April 2008)</i><br /><br />The ion channel milieu present in a neuron in large part determines the inherent excitability of a given cell and is responsible for the translation of sensory transduction and synaptic input to axonal output. Intrinsic excitability is a dynamic process subject to multiple levels of regulation from channel gene expression to post-translational modifications that influence channel activity. The goal of this review is to provide an overview of some of the mechanisms by which channels can be modified in order to influence neuronal output. We focus on four levels of regulation: channel gene transcription, alternative splicing of channel transcripts, post-translational modifications that alter channel kinetics (phosphorylation), and subcellular localization and trafficking of channel proteins. Mechanisms of voltage-gated ion channel regulation: from gene expression to localization. D Schulz S Temporal D Barry M Garcia doi:10.1007/s00018-008-8060-z Cellular and molecular life sciences : CMLS (14 April 2008) 2008-04-24T08:09:07-00:00 2008 Cellular and molecular life sciences : CMLS 1420-682X ion_channels nav phosphorylation review trafficking