Sun, 20 Jul 2008 21:33:02 BST CiteULike: klouie ofc http://www.citeulike.org/user/klouie/tag/ofc CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/klouie/article/2844657 <i>J. Neurosci., Vol. 28, No. 22. (28 May 2008), pp. 5623-5630.</i><br /><br />To make sound economic decisions, the brain needs to compute several different value-related signals. These include goal values that measure the predicted reward that results from the outcome generated by each of the actions under consideration, decision values that measure the net value of taking the different actions, and prediction errors that measure deviations from individuals' previous reward expectations. We used functional magnetic resonance imaging and a novel decision-making paradigm to dissociate the neural basis of these three computations. Our results show that they are supported by different neural substrates: goal values are correlated with activity in the medial orbitofrontal cortex, decision values are correlated with activity in the central orbitofrontal cortex, and prediction errors are correlated with activity in the ventral striatum. 10.1523/JNEUROSCI.1309-08.2008 Dissociating the Role of the Orbitofrontal Cortex and the Striatum in the Computation of Goal Values and Prediction Errors Todd Hare John O'Doherty Colin Camerer Wolfram Schultz Antonio Rangel doi:10.1523/JNEUROSCI.1309-08.2008 J. Neurosci., Vol. 28, No. 22. (28 May 2008), pp. 5623-5630. 2008-05-29T14:39:09-00:00 2008 J. Neurosci. 28 22 5623 5630 decisionmaking fmri neuroeconomics neuroimaging ofc reward value ventral_striatum http://www.citeulike.org/user/klouie/article/841288 <i>Curr Biol, Vol. 16, No. 15. (8 August 2006)</i><br /><br />Modern economics no longer uses the concept of cardinal utility, which describes the value of a good independently of a comparison with another good. New electrophysiological recordings in primates performing economic choices suggest a neurological substrate for cardinal utility, a finding that economists should perhaps take note of. Neuroeconomics: cardinal utility in the orbitofrontal cortex? V Stuphorn doi:10.1016/j.cub.2006.07.005 Curr Biol, Vol. 16, No. 15. (8 August 2006) 2006-09-12T18:59:31-00:00 2006 Curr Biol 0960-9822 16 15 neuroeconomics ofc review reward utility value http://www.citeulike.org/user/klouie/article/822558 <i>Nature Neuroscience, Vol. 9, No. 9. (20 August 2006), pp. 1161-1168.</i> Separate neural pathways process different decision costs Peter Rudebeck Mark Walton Angharad Smyth David Bannerman Matthew Rushworth doi:10.1038/nn1756 Nature Neuroscience, Vol. 9, No. 9. (20 August 2006), pp. 1161-1168. 2006-08-31T02:38:59-00:00 2006 Nature Neuroscience 1097-6256 9 9 1161 1168 Nature Publishing Group cingulate discounting lesion ofc rat reward http://www.citeulike.org/user/klouie/article/310495 <i>Nature Reviews Neuroscience, Vol. 6, No. 9. (01 September 2005), pp. 691-702.</i> The human orbitofrontal cortex: linking reward to hedonic experience Morten Kringelbach doi:10.1038/nrn1747 Nature Reviews Neuroscience, Vol. 6, No. 9. (01 September 2005), pp. 691-702. 2005-09-01T16:26:05-00:00 2005 Nature Reviews Neuroscience 1471-003X 6 9 691 702 Nature Publishing Group human ofc orbitofrontal review reward http://www.citeulike.org/user/klouie/article/825559 <i>J Neurosci, Vol. 15, No. 7 Pt 1. (July 1995), pp. 4851-4867.</i><br /><br />The ventral striatum is considered an interface between limbic and motor systems. We followed the orbital and medial prefrontal circuit through the monkey basal ganglia by analyzing the projection from this cortical area to the ventral striatum and the representation of orbitofrontal cortex via the striatum, in the globus pallidus and substantia nigra. Following injections of Lucifer yellow and horse radish peroxidase into the medial ventral striatum, there is a very densely labeled distribution of cells in areas 13a and 13b, primarily in layers V and VI, and in medial prefrontal areas 32 and 25. Injections into the shell of the nucleus accumbens labeled primarily areas 25 and 32. The reaction product in the globus pallidus and the substantia nigra supports previous studies demonstrating that efferent projections from the ventral striatum are represented topographically in the ventral pallidum and nontopographically in the substantia nigra, pars compacta. Tritiated amino acid or PHA-L tracer injections into orbitofrontal cortex produce dense patches of terminal labeling along the medial edge of the caudate nucleus and the dorsal part of the nucleus accumbens. These results demonstrate that the orbital prefrontal cortex projects primarily to the medial edge of the ventral striatum and to the core of the nucleus accumbens. The arrangement of terminals in the globus pallidus and substantia nigra show two different patterns. Thus, the orbital and medial prefrontal cortex is represented in a confined region of the globus pallidus but throughout an extensive area of the dorsal substantia nigra. Terminals are extensive throughout the region of the dopaminergic neurons, suggesting that this input may influence a wide area of both the striatum and frontal cortex. The orbital and medial prefrontal circuit through the primate basal ganglia. SN Haber K Kunishio M Mizobuchi E Lynd-Balta J Neurosci, Vol. 15, No. 7 Pt 1. (July 1995), pp. 4851-4867. 2006-09-01T21:32:56-00:00 1995 J Neurosci 0270-6474 15 7 Pt 1 4851 4867 monkey neuroanatomy ofc ventral_striatum http://www.citeulike.org/user/klouie/article/596542 <i>Nature (23 April 2006)</i> Neurons in the orbitofrontal cortex encode economic value Camillo Padoa-Schioppa John Assad doi:10.1038/nature04676 Nature (23 April 2006) 2006-04-24T03:07:43-00:00 2006 Nature 0028-0836 Nature Publishing Group monkey neuroeconomics neurophysiology ofc reward