Thu, 21 Aug 2008 15:26:02 BST CiteULike: klouie Brody http://www.citeulike.org/user/klouie/author/Brody CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/klouie/article/126957 <i>Science, Vol. 307, No. 5712. (18 February 2005), pp. 1121-1124.</i><br /><br />Networks adapt to environmental demands by switching between distinct dynamical behaviors. The activity of frontal-lobe neurons during two-interval discrimination tasks is an example of these adaptable dynamics. Subjects first perceive a stimulus, then hold it in working memory, and finally make a decision by comparing it with a second stimulus. We present a simple mutual-inhibition network model that captures all three task phases within a single framework. The model integrates both working memory and decision making because its dynamical properties are easily controlled without changing its connectivity. Mutual inhibition between nonlinear units is a useful design motif for networks that must display multiple behaviors. Flexible Control of Mutual Inhibition: A Neural Model of Two-Interval Discrimination Christian Machens Ranulfo Romo Carlos Brody doi:10.1126/science.1104171 Science, Vol. 307, No. 5712. (18 February 2005), pp. 1121-1124. 2005-03-14T21:51:08-00:00 2005 Science 307 5712 1121 1124 computationalmodel decisionmaking workingmemory