Sat, 05 Jul 2008 04:05:45 BST CiteULike: jyuh Münsterkötter http://www.citeulike.org/user/jyuh/author/Münsterkötter CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/jyuh/article/2782605 <i>Nucleic acids research, Vol. 36, No. Database issue. (January 2008)</i><br /><br />The Munich Information Center for Protein Sequences (MIPS-GSF, Neuherberg, Germany) combines automatic processing of large amounts of sequences with manual annotation of selected model genomes. Due to the massive growth of the available data, the depth of annotation varies widely between independent databases. Also, the criteria for the transfer of information from known to orthologous sequences are diverse. To cope with the task of global in-depth genome annotation has become unfeasible. Therefore, our efforts are dedicated to three levels of annotation: (i) the curation of selected genomes, in particular from fungal and plant taxa (e.g. CYGD, MNCDB, MatDB), (ii) the comprehensive, consistent, automatic annotation employing exhaustive methods for the computation of sequence similarities and sequence-related attributes as well as the classification of individual sequences (SIMAP, PEDANT and FunCat) and (iii) the compilation of manually curated databases for protein interactions based on scrutinized information from the literature to serve as an accepted set of reliable annotated interaction data (MPACT, MPPI, CORUM). All databases and tools described as well as the detailed descriptions of our projects can be accessed through the MIPS web server (http://mips.gsf.de). MIPS: analysis and annotation of genome information in 2007. HW Mewes S Dietmann D Frishman R Gregory G Mannhaupt KF Mayer M Münsterkötter A Ruepp M Spannagl V Stümpflen T Rattei Nucleic acids research, Vol. 36, No. Database issue. (January 2008) 2008-05-10T08:57:38-00:00 2008 Nucleic acids research 1362-4962 36 Database issue no-tag