CiteULike: brembs instrumental http://www.citeulike.org/user/brembs/tag/instrumental CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/brembs/article/1206070 <i>Trends in Neurosciences, Vol. In Press, Corrected Proof</i><br /><br />There are several brain regions that have been implicated in the control of motivated behavior and whose disruption leads to the pathophysiology observed in major psychiatric disorders. These systems include the ventral hippocampus, which is involved in context and focus on tasks, the amygdala, which mediates emotional behavior, and the prefrontal cortex, which modulates activity throughout the limbic system to enable behavioral flexibility. Each of these systems has overlapping projections to the nucleus accumbens, where these inputs are integrated under the modulatory influence of dopamine. Here, we provide a systems-oriented approach to interpreting the function of the dopamine system, its modulation of limbic-cortical interactions and how disruptions within this system might underlie the pathophysiology of schizophrenia and drug abuse. Regulation of firing of dopaminergic neurons and control of goal-directed behaviors Anthony Grace Stan Floresco Yukiori Goto Daniel Lodge doi:10.1016/j.tins.2007.03.003 Trends in Neurosciences, Vol. In Press, Corrected Proof 2007-04-04T14:05:09-00:00 Trends in Neurosciences In Press, Corrected Proof behavior decision-making habit instrumental learning neurobiology neuroscience operant psychology http://www.citeulike.org/user/brembs/article/1070682 <i>Nature Neuroscience, Vol. 10, No. 2. (21 January 2007), pp. 148-149.</i> Inducing motor skill improvements with a declarative task Rachel Brown Edwin Robertson doi:10.1038/nn1836 Nature Neuroscience, Vol. 10, No. 2. (21 January 2007), pp. 148-149. 2007-01-27T11:53:32-00:00 Nature Neuroscience 1097-6256 10 2 148 149 Nature Publishing Group classical conditioning habit instrumental neurobiology neuroscience operant pavlovian skill http://www.citeulike.org/user/brembs/article/1023152 <i>Cell, Vol. 127, No. 7. (29 December 2006), pp. 1453-1467.</i><br /><br />SummaryMolecular analyses of Aplysia, a well-established model organism for cellular and systems neural science, have been seriously handicapped by a lack of adequate genomic information. By sequencing cDNA libraries from the central nervous system (CNS), we have identified over 175,000 expressed sequence tags (ESTs), of which 19,814 are unique neuronal gene products and represent 50%-70% of the total Aplysia neuronal transcriptome. We have characterized the transcriptome at three levels: (1) the central nervous system, (2) the elementary components of a simple behavior: the gill-withdrawal reflex--by analyzing sensory, motor, and serotonergic modulatory neurons, and (3) processes of individual neurons. In addition to increasing the amount of available gene sequences of Aplysia by two orders of magnitude, this collection represents the largest database available for any member of the Lophotrochozoa and therefore provides additional insights into evolutionary strategies used by this highly successful diversified lineage, one of the three proposed superclades of bilateral animals. Neuronal Transcriptome of Aplysia: Neuronal Compartments and Circuitry Leonid Moroz John Edwards Sathyanarayanan Puthanveettil Andrea Kohn Thomas Ha Andreas Heyland Bjarne Knudsen Anuj Sahni Fahong Yu Li Liu doi:10.1016/j.cell.2006.09.052 Cell, Vol. 127, No. 7. (29 December 2006), pp. 1453-1467. 2007-01-03T10:18:42-00:00 Cell 127 7 1453 1467 aplysia classical conditioning instrumental invertebrate neurobiology neuroscience operant pavlovian