How Prior Reward Experience Biases Exploratory Movements: a Probabilistic Model.

@article{citeulike:941586, abstract = {Animals return to rewarded locations. An example of this is Conditioned Place Preference (CPP) which is widely used in studies of drug reward. Although CPP is expressed as increased time spent in a previously rewarded location, the behavioral strategy underlying this change is unknown. We continuously monitored rats (n = 22) in a three room in-line configuration, before and after morphine conditioning in one end room. Although sequential room visit durations were variable, their probability distribution was exponential, indicating that the processes controlling visit durations can be modeled by instantaneous room exit probabilities. Further analysis of room transitions and computer simulations of probabilistic models revealed that the exploratory bias toward the morphine room is best explained by an increase in the probability of a subset of rapid, direct transitions from the saline to the morphine paired room via the central room. This finding sharply delineates and constrains possible neural mechanisms for a class of self initiated, goal directed behaviors toward previously rewarded locations.}, address = {Department of Neurology, University of California San Francisco, San Francisco, California, United States.}, author = {German, Paul Walter W. and Fields, Howard L L. }, citeulike-article-id = {941586}, doi = {http://dx.doi.org/10.1152/jn.00303.2006}, issn = {0022-3077}, journal = {J Neurophysiol}, keywords = {\_note, behavior, cpp, morphine, rat, reward}, month = {November}, posted-at = {2006-12-18 23:37:33}, priority = {2}, title = {How Prior Reward Experience Biases Exploratory Movements: a Probabilistic Model.}, url = {http://dx.doi.org/10.1152/jn.00303.2006}, year = {2006} }

TY - JOUR ID - citeulike:941586 L3 - citeulike-article-id:941586 TI - How Prior Reward Experience Biases Exploratory Movements: a Probabilistic Model. JF - J Neurophysiol AD - Department of Neurology, University of California San Francisco, San Francisco, California, United States. SN - 0022-3077 N2 - Animals return to rewarded locations. An example of this is Conditioned Place Preference (CPP) which is widely used in studies of drug reward. Although CPP is expressed as increased time spent in a previously rewarded location, the behavioral strategy underlying this change is unknown. We continuously monitored rats (n = 22) in a three room in-line configuration, before and after morphine conditioning in one end room. Although sequential room visit durations were variable, their probability distribution was exponential, indicating that the processes controlling visit durations can be modeled by instantaneous room exit probabilities. Further analysis of room transitions and computer simulations of probabilistic models revealed that the exploratory bias toward the morphine room is best explained by an increase in the probability of a subset of rapid, direct transitions from the saline to the morphine paired room via the central room. This finding sharply delineates and constrains possible neural mechanisms for a class of self initiated, goal directed behaviors toward previously rewarded locations. KW - _note KW - behavior KW - cpp KW - morphine KW - rat KW - reward AU - German, Paul Walter AU - Fields, Howard L PY - 2006/11/08/ UR - http://dx.doi.org/10.1152/jn.00303.2006 ER -