Phase locking of single neuron activity to theta oscillations during working memory in monkey extrastriate visual cortex.

@article{citeulike:90344, abstract = {Working memory has been linked to elevated single neuron discharge in monkeys and to oscillatory changes in the human EEG, but the relation between these effects has remained largely unexplored. We addressed this question by measuring local field potentials and single unit activity simultaneously from multiple electrodes placed in extrastriate visual cortex while monkeys were performing a working memory task. We describe a significant enhancement in theta band energy during the delay period. Theta oscillations had a systematic effect on single neuron activity, with neurons emitting more action potentials near their preferred angle of each theta cycle. Sample-selective delay activity was enhanced if only action potentials emitted near the preferred theta angle were considered. Our results suggest that extrastriate visual cortex is involved in short-term maintenance of information and that theta oscillations provide a mechanism for structuring the recurrent interaction between neurons in different brain regions that underlie working memory.}, address = {Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, D-72076 T\"{u}bingen, Germany.}, author = {Lee, H. and Simpson, G. V. and Logothetis, N. K. and Rainer, G. }, citeulike-article-id = {90344}, doi = {10.1016/j.neuron.2004.12.025}, issn = {0896-6273}, journal = {Neuron}, keywords = {lfp, monkey, neurophysiology, phaselocking, theta, v4, workingmemory}, month = {January}, number = {1}, pages = {147--156}, posted-at = {2005-02-08 14:17:37}, priority = {2}, title = {Phase locking of single neuron activity to theta oscillations during working memory in monkey extrastriate visual cortex.}, url = {http://dx.doi.org/10.1016/j.neuron.2004.12.025}, volume = {45}, year = {2005} }

TY - JOUR ID - citeulike:90344 L3 - citeulike-article-id:90344 TI - Phase locking of single neuron activity to theta oscillations during working memory in monkey extrastriate visual cortex. JF - Neuron VL - 45 IS - 1 SP - 147 EP - 156 AD - Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, D-72076 Tübingen, Germany. SN - 0896-6273 N2 - Working memory has been linked to elevated single neuron discharge in monkeys and to oscillatory changes in the human EEG, but the relation between these effects has remained largely unexplored. We addressed this question by measuring local field potentials and single unit activity simultaneously from multiple electrodes placed in extrastriate visual cortex while monkeys were performing a working memory task. We describe a significant enhancement in theta band energy during the delay period. Theta oscillations had a systematic effect on single neuron activity, with neurons emitting more action potentials near their preferred angle of each theta cycle. Sample-selective delay activity was enhanced if only action potentials emitted near the preferred theta angle were considered. Our results suggest that extrastriate visual cortex is involved in short-term maintenance of information and that theta oscillations provide a mechanism for structuring the recurrent interaction between neurons in different brain regions that underlie working memory. KW - lfp KW - monkey KW - neurophysiology KW - phaselocking KW - theta KW - v4 KW - workingmemory AU - Lee, H AU - Simpson, GV AU - Logothetis, NK AU - Rainer, G PY - 2005/01/06/ UR - http://dx.doi.org/10.1016/j.neuron.2004.12.025 ER -