VisANT: an integrative framework for networks in systems biology

@article{HSD+08, abstract = {The essence of a living cell is adaptation to a changing environment, and a central goal of modern cell biology is to understand adaptive change under normal and pathological conditions. Because the number of components is large, and processes and conditions are many, visual tools are useful in providing an overview of relations that would otherwise be far more difficult to assimilate. Historically, representations were static pictures, with genes and proteins represented as nodes, and known or inferred correlations between them (links) represented by various kinds of lines. The modern challenge is to capture functional hierarchies and adaptation to environmental change, and to discover pathways and processes embedded in known data, but not currently recognizable. Among the tools being developed to meet this challenge is VisANT (freely available at http://visant.bu.edu) which integrates, mines and displays hierarchical information. Challenges to integrating modeling (discrete or continuous) and simulation capabilities into such visual mining software are briefly discussed. 10.1093/bib/bbn020}, author = {Hu, Zhenjun and Snitkin, Evan S. and Delisi, Charles }, citeulike-article-id = {2773954}, doi = {10.1093/bib/bbn020}, journal = {Brief Bioinform}, keywords = {biology, graph, systems, visualization}, month = {May}, pages = {bbn020+}, posted-at = {2008-05-13 04:50:49}, priority = {5}, title = {VisANT: an integrative framework for networks in systems biology}, url = {http://dx.doi.org/10.1093/bib/bbn020}, year = {2008} }

TY - JOUR ID - HSD+08 L3 - citeulike-article-id:2773954 TI - VisANT: an integrative framework for networks in systems biology JF - Brief Bioinform SP - bbn020 N2 - The essence of a living cell is adaptation to a changing environment, and a central goal of modern cell biology is to understand adaptive change under normal and pathological conditions. Because the number of components is large, and processes and conditions are many, visual tools are useful in providing an overview of relations that would otherwise be far more difficult to assimilate. Historically, representations were static pictures, with genes and proteins represented as nodes, and known or inferred correlations between them (links) represented by various kinds of lines. The modern challenge is to capture functional hierarchies and adaptation to environmental change, and to discover pathways and processes embedded in known data, but not currently recognizable. Among the tools being developed to meet this challenge is VisANT (freely available at http://visant.bu.edu) which integrates, mines and displays hierarchical information. Challenges to integrating modeling (discrete or continuous) and simulation capabilities into such visual mining software are briefly discussed. 10.1093/bib/bbn020 KW - biology KW - graph KW - systems KW - visualization AU - Hu, Zhenjun AU - Snitkin, Evan AU - Delisi, Charles PY - 2008/05/07/ UR - http://dx.doi.org/10.1093/bib/bbn020 ER -