Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs

by: F Roch, F Serras, FJ Cifuentes, M Corominas, B Alsina, M Amorós, A López-Varea, R Hernández, D Guerra, S Cavicchi, J Baguñá, A García-Bellido

Molecular and General Genetics MGG, Vol. 257, No. 2. (22 January 1998), pp. 103-112.

View FullText article

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

wrowell, Cline_lab (group)

Find related articles with these CiteULike tags

no-tag

Abstract

We have carried out screens for lethal mutations on the second chromosome of Drosophila melanogaster that are associated with abnormal imaginal disc morphologies, particularly in the wing disc. From a collection of 164 P element-induced mutations with a late larva/pupa lethal phase we have identified 56 new loci whose gene products are required for normal wing disc development and for normal morphology of other larval organs. Genetic mosaics of these 56 mutant lines show clonal mutant phenotypes for 23 cell-viable mutations. These phenotypes result from altered cell parameters. Causal relationships between disc and clonal phenotypes are discussed.

@article{citeulike:1643093, abstract = {We have carried out screens for lethal mutations on the second chromosome of Drosophila melanogaster that are associated with abnormal imaginal disc morphologies, particularly in the wing disc. From a collection of 164 P element-induced mutations with a late larva/pupa lethal phase we have identified 56 new loci whose gene products are required for normal wing disc development and for normal morphology of other larval organs. Genetic mosaics of these 56 mutant lines show clonal mutant phenotypes for 23 cell-viable mutations. These phenotypes result from altered cell parameters. Causal relationships between disc and clonal phenotypes are discussed.}, author = {Roch, F. and Serras, F. and Cifuentes, F. J. and Corominas, M. and Alsina, B. and Amor\'{o}s, M. and L\'{o}pez-Varea, A. and Hern\'{a}ndez, R. and Guerra, D. and Cavicchi, S. and Bagu\~{n}\'{a}, J. and Garc\'{i}a-Bellido, A. }, citeulike-article-id = {1643093}, doi = {http://dx.doi.org/10.1007/PL00008620}, journal = {Molecular and General Genetics MGG}, month = {January}, number = {2}, pages = {103--112}, posted-at = {2007-09-11 02:44:21}, priority = {2}, title = {Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs}, url = {http://dx.doi.org/10.1007/PL00008620}, volume = {257}, year = {1998} }

RIS record

TY - JOUR ID - citeulike:1643093 L3 - citeulike-article-id:1643093 TI - Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs JF - Molecular and General Genetics MGG VL - 257 IS - 2 SP - 103 EP - 112 N2 - We have carried out screens for lethal mutations on the second chromosome of Drosophila melanogaster that are associated with abnormal imaginal disc morphologies, particularly in the wing disc. From a collection of 164 P element-induced mutations with a late larva/pupa lethal phase we have identified 56 new loci whose gene products are required for normal wing disc development and for normal morphology of other larval organs. Genetic mosaics of these 56 mutant lines show clonal mutant phenotypes for 23 cell-viable mutations. These phenotypes result from altered cell parameters. Causal relationships between disc and clonal phenotypes are discussed. AU - Roch, F AU - Serras, F AU - Cifuentes, FJ AU - Corominas, M AU - Alsina, B AU - Amorós, M AU - López-Varea, A AU - Hernández, R AU - Guerra, D AU - Cavicchi, S AU - Baguñá, J AU - García-Bellido, A PY - 1998/01/22/ UR - http://dx.doi.org/10.1007/PL00008620 ER -

RIS BibTeX