New insights into the BzdR-mediated transcriptional regulation of the anaerobic catabolism of benzoate in Azoarcus sp. CIB

by: Gonzalo Durante-Rodriguez, Teresa M Zamarro, Jose L Garcia, Eduardo Diaz, Manuel Carmona

Microbiology, Vol. 154, No. 1. (1 January 2008), pp. 306-316.

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Abstract

The expression of the bzd genes involved in the anaerobic degradation of benzoate in Azoarcus sp. CIB is controlled by the specific BzdR transcriptional repressor at the PN promoter. This catabolic promoter is also subject to catabolite repression by some organic acids. In vivo and in vitro experiments have shown that BzdR behaves as a repressor of the PR promoter by overlapping the transcription initiation site as well as the -35 and -10 boxes, benzoyl-CoA being the inducer molecule. In addition, by using a PN : : lacZ fusion both in Azoarcus sp. CIB and in an isogenic strain lacking the bzdR gene, we have shown that the succinate-dependent catabolite repression requires participation of the BzdR repressor. 10.1099/mic.0.2007/011361-0

@article{citeulike:3024781, abstract = {The expression of the bzd genes involved in the anaerobic degradation of benzoate in Azoarcus sp. CIB is controlled by the specific BzdR transcriptional repressor at the PN promoter. This catabolic promoter is also subject to catabolite repression by some organic acids. In vivo and in vitro experiments have shown that BzdR behaves as a repressor of the PR promoter by overlapping the transcription initiation site as well as the -35 and -10 boxes, benzoyl-CoA being the inducer molecule. In addition, by using a PN : : lacZ fusion both in Azoarcus sp. CIB and in an isogenic strain lacking the bzdR gene, we have shown that the succinate-dependent catabolite repression requires participation of the BzdR repressor. 10.1099/mic.0.2007/011361-0}, author = {Durante-Rodriguez, Gonzalo and Zamarro, Teresa M. and Garcia, Jose L. and Diaz, Eduardo and Carmona, Manuel }, citeulike-article-id = {3024781}, doi = {10.1099/mic.0.2007/011361-0}, journal = {Microbiology}, keywords = {benzoate, biodegradation, bzdr, for-the-review, new-family, regulation, transcription}, month = {January}, number = {1}, pages = {306--316}, posted-at = {2008-07-21 16:54:49}, priority = {3}, title = {New insights into the BzdR-mediated transcriptional regulation of the anaerobic catabolism of benzoate in Azoarcus sp. CIB}, url = {http://dx.doi.org/10.1099/mic.0.2007/011361-0}, volume = {154}, year = {2008} }

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TY - JOUR ID - citeulike:3024781 L3 - citeulike-article-id:3024781 TI - New insights into the BzdR-mediated transcriptional regulation of the anaerobic catabolism of benzoate in Azoarcus sp. CIB JF - Microbiology VL - 154 IS - 1 SP - 306 EP - 316 N2 - The expression of the bzd genes involved in the anaerobic degradation of benzoate in Azoarcus sp. CIB is controlled by the specific BzdR transcriptional repressor at the PN promoter. This catabolic promoter is also subject to catabolite repression by some organic acids. In vivo and in vitro experiments have shown that BzdR behaves as a repressor of the PR promoter by overlapping the transcription initiation site as well as the -35 and -10 boxes, benzoyl-CoA being the inducer molecule. In addition, by using a PN : : lacZ fusion both in Azoarcus sp. CIB and in an isogenic strain lacking the bzdR gene, we have shown that the succinate-dependent catabolite repression requires participation of the BzdR repressor. 10.1099/mic.0.2007/011361-0 KW - benzoate KW - biodegradation KW - bzdr KW - for-the-review KW - new-family KW - regulation KW - transcription AU - Durante-Rodriguez, Gonzalo AU - Zamarro, Teresa AU - Garcia, Jose AU - Diaz, Eduardo AU - Carmona, Manuel PY - 2008/01/01/ UR - http://dx.doi.org/10.1099/mic.0.2007/011361-0 ER -

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