The diversity of connexin genes encoding gap junctional proteins.

@article{citeulike:1386786, abstract = {The multigene family of connexins is larger than previously anticipated. Ten different connexin homologous sequences have been characterized in the mouse genome, five of which are probably the mouse analogues of the known rat connexins26, -31, -32, -43, and -46. Since the additional 5 sequences have been isolated as cDNAs or hybridize specifically to distinct mRNA species, they most likely represent functional connexin genes. Since seven of the genomic connexin sequences have been shown to contain no intron in the coding sequence, this may apply to all mammalian connexin genes. Some of the structural features based on amino acid sequences deduced from cDNA or genomic sequences and the RNA expression pattern of the new connexins are compared with previously described connexins. The structural diversity of the connexin genes suggests that they fulfill different functions coordinated with, and perhaps required for, different programs of cellular differentiation.}, address = {Institut f\"{u}r Genetik (Abt. Molekulargenetik) Universit\"{a}t, Bonn/Bundersrepublik Deutschland.}, author = {Willecke, K. and Hennemann, H. and Dahl, E. and Jungbluth, S. and Heynkes, R. }, citeulike-article-id = {1386786}, issn = {0171-9335}, journal = {Eur J Cell Biol}, keywords = {connexin, electrophysiology, medsci733, sensitivity, techniques, voltage}, month = {October}, number = {1}, pages = {1--7}, posted-at = {2007-06-13 09:29:10}, priority = {2}, title = {The diversity of connexin genes encoding gap junctional proteins.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/1666038}, volume = {56}, year = {1991} }

TY - JOUR ID - citeulike:1386786 L3 - citeulike-article-id:1386786 TI - The diversity of connexin genes encoding gap junctional proteins. JF - Eur J Cell Biol VL - 56 IS - 1 SP - 1 EP - 7 AD - Institut für Genetik (Abt. Molekulargenetik) Universität, Bonn/Bundersrepublik Deutschland. SN - 0171-9335 N2 - The multigene family of connexins is larger than previously anticipated. Ten different connexin homologous sequences have been characterized in the mouse genome, five of which are probably the mouse analogues of the known rat connexins26, -31, -32, -43, and -46. Since the additional 5 sequences have been isolated as cDNAs or hybridize specifically to distinct mRNA species, they most likely represent functional connexin genes. Since seven of the genomic connexin sequences have been shown to contain no intron in the coding sequence, this may apply to all mammalian connexin genes. Some of the structural features based on amino acid sequences deduced from cDNA or genomic sequences and the RNA expression pattern of the new connexins are compared with previously described connexins. The structural diversity of the connexin genes suggests that they fulfill different functions coordinated with, and perhaps required for, different programs of cellular differentiation. KW - connexin KW - electrophysiology KW - medsci733 KW - sensitivity KW - techniques KW - voltage AU - Willecke, K AU - Hennemann, H AU - Dahl, E AU - Jungbluth, S AU - Heynkes, R PY - 1991/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/1666038 ER -