Prediction of protein three-dimensional structures in insertion and deletion regions: a procedure for searching data bases of representative protein fragments using geometric scoring criteria.

@article{citeulike:638323, abstract = {The prediction of protein structure in insertion/deletion regions (referred to as indels) is an important part of protein model building by homology. Here we combine cluster analysis with data base search procedures. Initially, data bases of representative protein fragments are constructed using two different clustering algorithms. In the HCAPD (hierarchical clustering after preliminary division) approach, all protein fragments are divided into classes with similar anchor region structures (a protein fragment consists of two anchoring regions and a central region). Within these classes the fragments are further clustered using a hierarchical cluster algorithm. The DCANN (deterministic clustering by assignment of all nearest neighbours) approach is a variant of the k-nearest neighbours cluster algorithm. Only geometric scoring criteria are used for data base searching. The main advantage of a non-redundant data base is the ability to provide structurally different fragments during the search process, which leads to an improvement in structure prediction. Both methods have been tested on 71 insertions and 74 deletions with lengths between one and eight residues.}, address = {GBF (Gesellschaft f\"{u}r Biotechnologische Forschung) Department of Molecular Structure Research, Braunschweig, Germany.}, author = {Fechteler, T. and Dengler, U. and Schomburg, D. }, citeulike-article-id = {638323}, doi = {10.1006/jmbi.1995.0540}, issn = {0022-2836}, journal = {J Mol Biol}, keywords = {bioinformatics, protein\_fragments, structure\_prediction}, month = {October}, number = {1}, pages = {114--131}, posted-at = {2006-05-19 18:30:30}, priority = {2}, title = {Prediction of protein three-dimensional structures in insertion and deletion regions: a procedure for searching data bases of representative protein fragments using geometric scoring criteria.}, url = {http://dx.doi.org/10.1006/jmbi.1995.0540}, volume = {253}, year = {1995} }

TY - JOUR ID - citeulike:638323 L3 - citeulike-article-id:638323 TI - Prediction of protein three-dimensional structures in insertion and deletion regions: a procedure for searching data bases of representative protein fragments using geometric scoring criteria. JF - J Mol Biol VL - 253 IS - 1 SP - 114 EP - 131 AD - GBF (Gesellschaft für Biotechnologische Forschung) Department of Molecular Structure Research, Braunschweig, Germany. SN - 0022-2836 N2 - The prediction of protein structure in insertion/deletion regions (referred to as indels) is an important part of protein model building by homology. Here we combine cluster analysis with data base search procedures. Initially, data bases of representative protein fragments are constructed using two different clustering algorithms. In the HCAPD (hierarchical clustering after preliminary division) approach, all protein fragments are divided into classes with similar anchor region structures (a protein fragment consists of two anchoring regions and a central region). Within these classes the fragments are further clustered using a hierarchical cluster algorithm. The DCANN (deterministic clustering by assignment of all nearest neighbours) approach is a variant of the k-nearest neighbours cluster algorithm. Only geometric scoring criteria are used for data base searching. The main advantage of a non-redundant data base is the ability to provide structurally different fragments during the search process, which leads to an improvement in structure prediction. Both methods have been tested on 71 insertions and 74 deletions with lengths between one and eight residues. KW - bioinformatics KW - protein_fragments KW - structure_prediction AU - Fechteler, T AU - Dengler, U AU - Schomburg, D PY - 1995/10/13/ UR - http://dx.doi.org/10.1006/jmbi.1995.0540 ER -