Metabolism of [alpha]-linolenic acid in humans

@article{citeulike:990181, abstract = {[alpha]-Linolenic acid (18:3n-3) is essential in the human diet, probably because it is the substrate for the synthesis of longer-chain, more unsaturated n-3 fatty acids eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) which are required for tissue function. This article reviews the recent literature on 18:3n-3 metabolism in humans, including fatty acid [beta]-oxidation, recycling of carbon by fatty acid synthesis de novo and conversion to longer-chain polyunsaturated fatty acids (PUFA). In men, stable isotope tracer studies and studies in which volunteers increased their consumption of 18:3n-3 show conversion to 20:5n-3 and 22:5n-3, but limited conversion to 22:6n-3. However, conversion to 18:3n-3 to 20:5n-3 and 22:6n-3 is greater in women compared to men, due possibly to a regulatory effect of oestrogen, while partitioning of 18:3n-3 towards [beta]-oxidation and carbon recycling was lower than in men. These gender differences may be an important consideration in making dietary recommendations for n-3 PUFA intake.}, author = {Burdge, G. C. }, booktitle = {Proceedings of the 7th Fatty Acid and Cell Signaling (FACS)workshop held in Paris on September 28-30, 2005}, citeulike-article-id = {990181}, doi = {http://dx.doi.org/10.1016/j.plefa.2006.05.013}, journal = {Prostaglandins, Leukotrienes and Essential Fatty Acids}, keywords = {diet, health, omega3}, month = {September}, number = {3}, pages = {161--168}, posted-at = {2006-12-12 21:41:43}, priority = {5}, title = {Metabolism of [alpha]-linolenic acid in humans}, url = {http://dx.doi.org/10.1016/j.plefa.2006.05.013}, volume = {75}, year = {2006} }

TY - JOUR ID - citeulike:990181 L3 - citeulike-article-id:990181 TI - Metabolism of [alpha]-linolenic acid in humans T2 - Proceedings of the 7th Fatty Acid and Cell Signaling (FACS)workshop held in Paris on September 28-30, 2005 JF - Prostaglandins, Leukotrienes and Essential Fatty Acids VL - 75 IS - 3 SP - 161 EP - 168 N2 - [alpha]-Linolenic acid (18:3n-3) is essential in the human diet, probably because it is the substrate for the synthesis of longer-chain, more unsaturated n-3 fatty acids eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) which are required for tissue function. This article reviews the recent literature on 18:3n-3 metabolism in humans, including fatty acid [beta]-oxidation, recycling of carbon by fatty acid synthesis de novo and conversion to longer-chain polyunsaturated fatty acids (PUFA). In men, stable isotope tracer studies and studies in which volunteers increased their consumption of 18:3n-3 show conversion to 20:5n-3 and 22:5n-3, but limited conversion to 22:6n-3. However, conversion to 18:3n-3 to 20:5n-3 and 22:6n-3 is greater in women compared to men, due possibly to a regulatory effect of oestrogen, while partitioning of 18:3n-3 towards [beta]-oxidation and carbon recycling was lower than in men. These gender differences may be an important consideration in making dietary recommendations for n-3 PUFA intake. KW - diet KW - health KW - omega3 AU - Burdge, GC PY - 2006/09// UR - http://dx.doi.org/10.1016/j.plefa.2006.05.013 ER -