Genetic Network Analyzer: qualitative simulation of genetic regulatory networks

by: Hidde de Jong, Johannes Geiselmann, Celine Hernandez, Michel Page

Bioinformatics, Vol. 19, No. 3. (12 February 2003), pp. 336-344.

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Abstract

Motivation: The study of genetic regulatory networks has received a major impetus from the recent development of experimental techniques allowing the measurement of patterns of gene expression in a massively parallel way. This experimental progress calls for the development of appropriate computer tools for the modeling and simulation of gene regulation processes. Results: We present Genetic Network Analyzer (GNA), a computer tool for the modeling and simulation of genetic regulatory networks. The tool is based on a qualitative simulation method that employs coarse-grained models of regulatory networks. The use of GNA is illustrated by a case study of the network of genes and interactions regulating the initiation of sporulation in Bacillus subtilis. Availability: GNA and the model of the sporulation network are available at http://www-helix.inrialpes.fr/gna Contact: Hidde.de-Jong@inrialpes.fr 10.1093/bioinformatics/btf851

@article{citeulike:671360, abstract = {Motivation: The study of genetic regulatory networks has received a major impetus from the recent development of experimental techniques allowing the measurement of patterns of gene expression in a massively parallel way. This experimental progress calls for the development of appropriate computer tools for the modeling and simulation of gene regulation processes. Results: We present Genetic Network Analyzer (GNA), a computer tool for the modeling and simulation of genetic regulatory networks. The tool is based on a qualitative simulation method that employs coarse-grained models of regulatory networks. The use of GNA is illustrated by a case study of the network of genes and interactions regulating the initiation of sporulation in Bacillus subtilis. Availability: GNA and the model of the sporulation network are available at http://www-helix.inrialpes.fr/gna Contact: Hidde.de-Jong@inrialpes.fr 10.1093/bioinformatics/btf851}, author = {de Jong, Hidde and Geiselmann, Johannes and Hernandez, Celine and Page, Michel }, citeulike-article-id = {671360}, journal = {Bioinformatics}, keywords = {network}, month = {February}, number = {3}, pages = {336--344}, posted-at = {2007-09-08 19:12:15}, priority = {3}, title = {Genetic Network Analyzer: qualitative simulation of genetic regulatory networks}, url = {http://bioinformatics.oxfordjournals.org/cgi/content/abstract/19/3/336}, volume = {19}, year = {2003} }

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TY - JOUR ID - citeulike:671360 L3 - citeulike-article-id:671360 TI - Genetic Network Analyzer: qualitative simulation of genetic regulatory networks JF - Bioinformatics VL - 19 IS - 3 SP - 336 EP - 344 N2 - Motivation: The study of genetic regulatory networks has received a major impetus from the recent development of experimental techniques allowing the measurement of patterns of gene expression in a massively parallel way. This experimental progress calls for the development of appropriate computer tools for the modeling and simulation of gene regulation processes. Results: We present Genetic Network Analyzer (GNA), a computer tool for the modeling and simulation of genetic regulatory networks. The tool is based on a qualitative simulation method that employs coarse-grained models of regulatory networks. The use of GNA is illustrated by a case study of the network of genes and interactions regulating the initiation of sporulation in Bacillus subtilis. Availability: GNA and the model of the sporulation network are available at http://www-helix.inrialpes.fr/gna Contact: Hidde.de-Jong@inrialpes.fr 10.1093/bioinformatics/btf851 KW - network AU - de Jong, Hidde AU - Geiselmann, Johannes AU - Hernandez, Celine AU - Page, Michel PY - 2003/02/12/ UR - http://bioinformatics.oxfordjournals.org/cgi/content/abstract/19/3/336 ER -

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