Osteoarthritis susceptibility loci defined by genome scan meta-analysis.

by: YH Lee, YH Rho, SJ Choi, JD Ji, GG Song

Rheumatol Int, Vol. 26, No. 11. (September 2006), pp. 996-1000.

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Abstract

Genome scans for osteoarthritis (OA) have yielded inconsistent results. The absence of replication of linkage might be due to the lack of power of individual studies. A meta-analysis of published data was performed to assess evidence for linkage of OA across genome scan studies. Three OA whole-genome scans including 893 families with 3,000 affected individuals were used for genome scan meta-analysis (GSMA). A total of five bins lie above 95% confidence level (P=0.05) and one bin is above 99% confidence level (P=0.01) in OA GSMA; bins 7.6 (7q34-7q36.3, P (sumrnk) =0.0035), 11.3 (11p12-11q13.4), 6.3 (6p21.1-6q15), 2.8 (2q31.1-2q34) and 15.3 (15q21.3-15q26.1). The highest summed bin was bins 7.6. In conclusion, the OA GSMA has shown that chromosome 7q34-7q36.3 have the highest summed rank and four additional loci with significant summed ranks across studies.

@article{citeulike:1391740, abstract = {Genome scans for osteoarthritis (OA) have yielded inconsistent results. The absence of replication of linkage might be due to the lack of power of individual studies. A meta-analysis of published data was performed to assess evidence for linkage of OA across genome scan studies. Three OA whole-genome scans including 893 families with 3,000 affected individuals were used for genome scan meta-analysis (GSMA). A total of five bins lie above 95\% confidence level (P=0.05) and one bin is above 99\% confidence level (P=0.01) in OA GSMA; bins 7.6 (7q34-7q36.3, P (sumrnk) =0.0035), 11.3 (11p12-11q13.4), 6.3 (6p21.1-6q15), 2.8 (2q31.1-2q34) and 15.3 (15q21.3-15q26.1). The highest summed bin was bins 7.6. In conclusion, the OA GSMA has shown that chromosome 7q34-7q36.3 have the highest summed rank and four additional loci with significant summed ranks across studies.}, address = {Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, 126-1 Ka, Anam-Dong Seongbuk-Ku, Seoul 136-705, South Korea. lyhcgh@korea.ac.kr}, author = {Lee, Y. H. and Rho, Y. H. and Choi, S. J. and Ji, J. D. and Song, G. G. }, citeulike-article-id = {1391740}, doi = {http://dx.doi.org/10.1007/s00296-006-0120-9}, issn = {0172-8172}, journal = {Rheumatol Int}, keywords = {gsma}, month = {September}, number = {11}, pages = {996--1000}, posted-at = {2007-06-15 11:15:14}, priority = {2}, title = {Osteoarthritis susceptibility loci defined by genome scan meta-analysis.}, url = {http://dx.doi.org/10.1007/s00296-006-0120-9}, volume = {26}, year = {2006} }

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TY - JOUR ID - citeulike:1391740 L3 - citeulike-article-id:1391740 TI - Osteoarthritis susceptibility loci defined by genome scan meta-analysis. JF - Rheumatol Int VL - 26 IS - 11 SP - 996 EP - 1000 AD - Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, 126-1 Ka, Anam-Dong Seongbuk-Ku, Seoul 136-705, South Korea. lyhcgh@korea.ac.kr SN - 0172-8172 N2 - Genome scans for osteoarthritis (OA) have yielded inconsistent results. The absence of replication of linkage might be due to the lack of power of individual studies. A meta-analysis of published data was performed to assess evidence for linkage of OA across genome scan studies. Three OA whole-genome scans including 893 families with 3,000 affected individuals were used for genome scan meta-analysis (GSMA). A total of five bins lie above 95% confidence level (P=0.05) and one bin is above 99% confidence level (P=0.01) in OA GSMA; bins 7.6 (7q34-7q36.3, P (sumrnk) =0.0035), 11.3 (11p12-11q13.4), 6.3 (6p21.1-6q15), 2.8 (2q31.1-2q34) and 15.3 (15q21.3-15q26.1). The highest summed bin was bins 7.6. In conclusion, the OA GSMA has shown that chromosome 7q34-7q36.3 have the highest summed rank and four additional loci with significant summed ranks across studies. KW - gsma AU - Lee, YH AU - Rho, YH AU - Choi, SJ AU - Ji, JD AU - Song, GG PY - 2006/09// UR - http://dx.doi.org/10.1007/s00296-006-0120-9 ER -

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