Population imaging of ongoing neuronal activity in the visual cortex of awake rats.

@article{citeulike:2906898, abstract = {It is unclear how the complex spatiotemporal organization of ongoing cortical neuronal activity recorded in anesthetized animals relates to the awake animal. We therefore used two-photon population calcium imaging in awake and subsequently anesthetized rats to follow action potential firing in populations of neurons across brain states, and examined how single neurons contributed to population activity. Firing rates and spike bursting in awake rats were higher, and pair-wise correlations were lower, compared with anesthetized rats. Anesthesia modulated population-wide synchronization and the relationship between firing rate and correlation. Overall, brain activity during wakefulness cannot be inferred using anesthesia.}, address = {[1] Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany. [2] Network Imaging Group, Max Planck Institute for Biological Cybernetics, Spemannstra{\ss}e 41, 72076 T\"{u}bingen, Germany. [3] These authors contributed equally to this work.}, author = {Greenberg, David S S. and Houweling, Arthur R R. and Kerr, Jason N D N. }, citeulike-article-id = {2906898}, doi = {10.1038/nn.2140}, issn = {1097-6256}, journal = {Nature neuroscience}, keywords = {sponta}, month = {June}, posted-at = {2008-06-19 10:04:00}, priority = {2}, title = {Population imaging of ongoing neuronal activity in the visual cortex of awake rats.}, url = {http://dx.doi.org/10.1038/nn.2140}, year = {2008} }

TY - JOUR ID - citeulike:2906898 L3 - citeulike-article-id:2906898 TI - Population imaging of ongoing neuronal activity in the visual cortex of awake rats. JF - Nature neuroscience AD - [1] Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany. [2] Network Imaging Group, Max Planck Institute for Biological Cybernetics, Spemannstraße 41, 72076 Tübingen, Germany. [3] These authors contributed equally to this work. SN - 1097-6256 N2 - It is unclear how the complex spatiotemporal organization of ongoing cortical neuronal activity recorded in anesthetized animals relates to the awake animal. We therefore used two-photon population calcium imaging in awake and subsequently anesthetized rats to follow action potential firing in populations of neurons across brain states, and examined how single neurons contributed to population activity. Firing rates and spike bursting in awake rats were higher, and pair-wise correlations were lower, compared with anesthetized rats. Anesthesia modulated population-wide synchronization and the relationship between firing rate and correlation. Overall, brain activity during wakefulness cannot be inferred using anesthesia. KW - sponta AU - Greenberg, David S AU - Houweling, Arthur R AU - Kerr, Jason N D PY - 2008/06/15/ UR - http://dx.doi.org/10.1038/nn.2140 ER -